Effect of repeat bolus dose of propofol on succinylcholine-induced fasciculations and myalgia

Effect of repeat bolus dose of propofol on succinylcholine-induced fasciculations and myalgia

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Background: Succinylcholine-induced fasciculations and myalgia are common and troublesome for the patients.A few studies have used propofol to minimize succinylcholine-induced fasciculations and myalgia, but none of these have used a repeat bolus dose.Materials and Methods: A prospective, randomized, double blind study was designed to assess the effect of a repeat bolus dose of propofol on succinylcholine-induced fasciculations and myalgia.Ninety adult patients scheduled for elective surgery under general anesthesia were selected by computer-generated random numbers and allocated to one of the three equal groups randomly.

Anesthesia was induced with intravenous injection of propofol 2 mg/kg, followed by administration of succinylcholine 1.5 mg/kg.Immediately after the injection of succinylcholine a repeat bolus of propofol was stuart products emcelle tocopherol given as per group.Group I: No repeat dose of propofol; Group II: Repeat propofol bolus of 0.

5 mg/kg body weight; Group III: Repeat propofol bolus of 1.0 mg/kg body weight.Muscle fasciculations were observed and graded as nil (0), mild (1), moderate (2), or severe (3).Postoperative myalgia were assessed every 6 hourly for 24 h and then at 48 h and graded as nil (I), mild (II), moderate (III), or severe (IV).

Results: The overall incidence of muscle fasciculations was 73 and 33% in Groups II and III, respectively as against 90% in Group I.The incidence of postoperative myalgia was highest (86.67%) in Group I and lowest in Group III (60.0%).

Conclusion: The technique of giving repeat bolus dose of propofol immediately after succinylcholine not only decreases the incidence and severity 6-0 igora vibrance of fasciculations and postoperative myalgia, but also provides hemodynamic stability and satisfactory grade of relaxation for intubation.